According to ProvoCraft, no buttttt I beg to differ, the answer is YES!!! If you have the new Vista 64 bit, do this. Install Design Studio. Right click on the DS icon and then click on Properties.
Next click on the Compatibility tab. Click on "Run this program in compatibility mode for:" and use the pull down window to add "Windows XP (Service Pack 2)" then go down to "Run this program as an administrator" and click it. Now click on OK and TA-DAAAAA!! It's done. Go ahead, try it!!!